Pyridazine is one of the important six-membered ring systems and an important chemical entity with the potentials to obtain its analogs with more advanced pharmacological effects[1]. As so far, pyridazines and their oxo-derivatives are known as the privileged heteroaromatic skeleton due to the important bioactivities associated with these compounds involving antihypertensive, antifungal, antiviral, anti-inflammatory, anticancer, anti-diabetic and antimicrobial activities[2-7]. Regarding this fact, there has been extensive attention toward the synthesis of novel compounds containing pyridazine moiety and evaluation their bioactivities[2].
[1] RSC Advances (2011), 1(3), 364-388.
[2] Bioorganic Chemistry (2020), 102, 104071. Doi: 10.1016/j.bioorg.2020.104071.
[3] Journal of Medicinal Chemistry (2020). Doi: 10.1021/acs.jmedchem.0c00346.
[4] Journal of Medicinal Chemistry (2020), 63(2), 756-783.
[5] European Journal of Medicinal Chemistry (2020), 190, 112092. Doi: 10.1016/j.ejmech. 2020.112092.
[6] European Journal of Medicinal Chemistry (2020), 187, 111912. Doi: 10.1016/j.ejmech. 2019.111912.
[7] Bioorganic Chemistry (2020), 95, 103497. Doi: 10.1016/j.bioorg. 2019.103497.
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